Leslie Meisel was born in Philadelphia. Her parents moved to South Florida when Leslie was a year old. After graduating with honors in Theatre from the University of Florida she moved to New York and started studying with Martin de Maat at the Second City NYTC. She then auditioned and became a cast member in The Second City Business Theatre New York Company. She continued her improv training at The Upright Citizens Brigade Theatre and performed on two improv Harold house teams. Her first one-woman show "You Never Know" premiered at The PIT (People's Improv Theatre) in March of 2005 and was listed as "One of the best shows of 2005" alongside Doubt, Pillowman, and Jersey Boys. Her most recent show "Love Can Suck A D**k...And So Can I!" - which was co-created with Megan Neuringer - sold out at UCBTLA and had a hit year long run at UCBTNY.