Born in Klamath Falls, Oregon, and raised in Portland, Brenda Bakke moved to Los Angeles to study acting at the American Academy of Dramatic Arts. She began to work in the mid-1980s on episodes of television series and playing minor characters in low budget comedies. She appeared in the Charlie Sheen film Hot Shots! Part Deux (1993). During the 1990s, she appeared in such mainstream Hollywood films as Under Siege 2: Dark Territory (1995) and L.A. Confidential (1997). The latter received nine Academy Award nominations, winning two Oscars. She landed a role on American Gothic (1995). In the 2000s, she appeared in such films as The Quickie (2001) and Moving August (2002). She had guest roles on episodes of CSI: Crime Scene Investigation (2000), NYPD Blue (1993), The Mentalist (2008), and Supernatural (2005). In 2015, she began appearing in the recurring role of Virginia on If Loving You Is Wrong (2014). In 2016-17, she appeared in guest star roles on Heartbeat (2016), Grey's Anatomy (2005), and Criminal Minds: Beyond Borders (2016).